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In the 1/1/04 Frontiers in Bioscience article titled "The history of SIVs and AIDS: epidemiology, phylogeny and biology of isolates from naturally SIV infected non-human primates (NHP) in Africa," Apetreietal. (Preston Marx is senior author) state: AIDS AS A ZOONOSIS? CONFUSION OVER THE ORIGIN OF THE VIRUS AND THE ORIGIN OF THE EPIDEMICS Based on results showing the simian origin of HIV,
AIDS was postulated as a zoonosis. This hypothesis was based on data
showing cross-species transmission, such as: Both SIVsm/HIV-2 and SIVcpz/HIV-1 fulfill these
criteria, however, although the hypothesis of simian origin of AIDS is
nowadays largely acknowledged, the idea that AIDS is a zoonosis has
never been proven and must be questioned. All these definitions show that the use of this term is questionable in the case of the emergence of AIDS pandemic. Several arguments are provided to support this objection: 1. In spite of the large exposure to SIV-infected monkeys in Central and West Africa, extensive molecular epidemiologic studies documented only 10 cross-species transmission events during the last century. Only four of these cross-over events resulted in epidemic strains: HIV-1 group M, the major group of viruses of the pandemic, group O, which is responsible for perhaps 5% of cases in Cameroon and groups A and B of HIV-2, which are the epidemic forms of HIV-2.
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The History of SIVs and Aids 1/1/04 Report |
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